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1 The essential finding of an association between GLP-1RAs and chronic cough didnt surprise me because we identified GERD as a likely mechanism, which is a very well-known side effect of GLP-1s, said Tyler J

Withdrawal effects from GLP-1 medications include increased hunger, food preoccupation, and in some cases, rapid weight regain of 5-10% within the first few months off treatment

The drugs increased demand is raising serious questions about Ozempic misuse and its potential to cause addiction or dependence

As far as what the oral GLP-1 means for the future of Lillys injectable Zepbound (tirzepatide), which saw $5 billion in sales last year (PharmaCircle Key Product Sales), the Lilly spokesperson says: Orforglipron and Zepbound have distinct mechanisms, formulations, and route of administration

Published October 22, 2025

Lactobacillus acidophilus can regulate intestinal endocrine cell function and promote GLP-1 secretion