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Nuclear receptor coactivator 4 (NCOA4) enhances free iron levels by binding to ferritin-heavy chains and aiding its transport through the lysosome

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SURMOUNT trial data showed tirzepatide patients achieving triglyceride reductions of up to 24% and HDL increases of up to 8% at the highest doses

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The primary effects of GLP-1 RA involve controlling blood glucose levels in individuals with T2DM by promoting glucose-dependent insulin release [67], inhibiting glucagon production, decreasing hepatic glucose output [68], improving insulin secretion, reducing the apoptosis of -cells, promoting the proliferation of -cells [69] and curbing weight gain [70]