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This systems-level activity has made it an important model for studies of skin physiology, connective tissue biology and regenerative signalling

Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

10.1016/j.cmet.2014.12.007 Cell Metab

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The following are the details on the adverse events the agency has received to date and the findings from FDAs investigation