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Emerging evidence suggests that ALC levels are reduced in individuals with MDD, and this deficiency may contribute to depressive symptoms through disruptions in mitochondrial fatty acid transport, neuroplasticity, and neurotransmission

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Yet only about 20% of adults got an updated booster when it was offered a year ago

2006;42(1):816 "Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology"