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Clinical Evidence in Alcohol Use Disorder Two clinical studies primarily investigated the effects of GLP-1 RAs in alcohol use disorder (AUD)

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This Lp(a) driven inflammation leads to endothelial dysfunction.[ref] Specifically, lipoprotein(a) and ApoA covalently bind with oxidized phospholipids at the site of distress or lesions in the endothelium

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Pharmacologically, GLP-1R is a G-protein coupled receptor (GPCR) critical for glucose homeostasis, which mediates the effects of GLP-1R agonists [26, 27]