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This metabolic perturbation, coupled with lactate-mediated feedback inhibition of phosphofructokinase-1, ultimately impairs cellular ATP homeostasis and compromises GSH biosynthesis, the predominant intracellular antioxidant (50)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Bandoli G., Palmsten K., Chambers C

Coffin, the lead researcher on the methamphetamine-addiction study, said that because the GLP-1 drug is designed to satiate, it can take away that need to always be trying to fill a hole inside of you. The theory has already shown initial promise in alcohol-addiction treatment, which is also being researched at UCSF