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Patients sensitive to preservatives may develop a skin rash, itching or, very rarely, a systemic reaction

For instance, the vitamin is required for the enzymatic reaction that synthesizes the neurotransmitter norepinephrine from dopamine

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[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Shin S., Wakabayashi J., Yates M.S., Wakabayashi N., Dolan P.M., Aja S., Liby K.T., Sporn M.B., Yamamoto M., Kensler T.W

Modern research is divided and every health expert seems to have a different opinion

However, without proper oral hygiene, bacteria can reach levels that might lead to oral infections, such as tooth decay and gum disease