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In trials directly comparing shorter- versus longer-acting GLP-1 receptor agonists, longer-acting had better glycemic efficacy
Semaglutide slows digestion and delays stomach emptying, which causes back flushing of gastric content into the esophagus and throat, leading to heartburn
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Likewise, I do not lack willpower
Yang Y, Zhang J, Ma D, Zhang M, Hu S, Shao S, et al
Topiramate may also be used long-term, but it requires regular monitoring due to potential side effects, including cognitive changes and kidney stones
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