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GLP-1 receptor agonists carry a labeled warning about pancreatitis, though large-scale reviews have questioned whether the association is causal

Indeed, in one study with daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study, l-ARG supplementation was found to significantly increase both plasma and urinary NO levels in patients with organic ED of mixed etiology and unknown severity [28], therefore potentially providing additional intracavernous NO supply

Cardiovascular and Laboratory Parameters: No clinically significant changes were observed in blood pressure, heart rate, ECG readings, or standard laboratory values including liver and kidney function tests

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