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Data were analyzed using GraphPad Prism v11.0.0

Available as a weekly subcutaneous injection for diabetes (Ozempic) or weight management (Wegovy), and as a daily oral tablet (Rybelsus) for diabetes only, semaglutide has demonstrated substantial weight loss and metabolic improvements in clinical trials

People often report that their measurements tell a more dramatic story than their weight, because the fat being lost is dense and centrally located

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Pharmacological interventions are more limited, with antidepressants such as duloxetine (a serotonin-noradrenaline reuptake inhibitor) or amitriptyline (a tricyclic antidepressant) sometimes considered