Class-wide precautions for GLP-1-based agents include a possible increased risk of pancreatitis, gallbladder issues, and based on rodent studies a boxed warning regarding medullary thyroid carcinoma, meaning it is contraindicated in people with a personal or family history of that cancer or of multiple endocrine neoplasia type 2
Theres no single best concentration
They studied 6,070 patients aged 24 and older, all with obesity (BMI 30) and type 2 diabetes diagnosed after age 21, treated between 2008 and 2021
Avoid known triggers: Alcohol, excessive heat, and prolonged standing can all exacerbate dizziness, particularly in the context of blood pressure changes
For an imperfect comparison, the discontinuation rate seen in the landmark STEP trials for semaglutide was around 7%
Freezing damages the peptide structure and reduces potency