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Whether we waited too long to respond to the COVID-19 outbreak, or not, we still must consider what proactive, preventable approaches could have better influenced such a familiar and predictable disaster, as medical and public health communities have long warned of the potential for such a pandemic (94)

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Prior to the roll-out of vaccines, the expansion of SARS-CoV-2-specific T cells and an interferon response were detectable in the blood even in the week preceding PCR positivity in asymptomatic and mild cases of primary SARS-CoV-2 infection [66]