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Furthermore, the activity of Rutin was verified, with IC 50 values of 40.95 M and 90.09 M for promastigotes and amastigotes, respectively, and no cytotoxicity at a concentration of 819.00 M

reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation

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