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Currently, in pre-clinical safety assessment studies, only a limited number of drug candidates (28%) are being rejected because of nephrotoxicity (Cook et al

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Clinical pharmacokinetics, pharmacodynamics, efficacy, and safety were evaluated in a phase 1/2 clinical trial (NCT05120830) [1,2]

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GERD is significantly prevalent in Western countries, affecting an estimated 10% to 20% of the population

We observed an H 2 O 2 concentration-dependent NADPH consumption in leaf discs from wild-type plants, which was similar in ntra/b plants, but completely absent in gr1 plants