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However, PPAR was downregulated in patients with NASH compared to patients with steatosis and healthy controls [75, 86], and the expression of PPAR decreased with increasing NAFLD activity score and fibrosis stage [86]

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Acceptance of these conclusions, of course, requires reconciliation with the finding that multiple mitochondrial respiratory complex subunits exhibited decreased expression in treated animals

(2023) investigated the immunomodulatory and anti-inflammatory properties of Embelin in LPS- induced AKI, revealing that Embelin can mitigate AKI by inhibiting M1 macrophage activation and blocking NF-B signaling in mice