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Intranodal administration of antigen plasmids (pMEL-TYR) and peptides (E-MEL and E-TYR) against Melan A Tyrosinase in patients with metastatic melanoma yielded an overall immune response rate of 50% (243)

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Lab review before starting: A baseline IGF-1, fasting glucose, and (where indicated) a thyroid panel sets the framework for response tracking