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Where source data could not be verified, the gap is documented rather than filled with assumption

Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

While niacinamide inhibits the transfer of melanosomes from melanocytes to keratinocytes, alpha-arbutin acts upstream in the process by inhibiting the activity of tyrosinase, the key enzyme in melanogenesis

Polydeoxyribonucleotide and the repair signal Polydeoxyribonucleotide, usually shortened to PDRN, is a low-molecular-weight DNA fragment that has become one of the more researched regenerative ingredients in skin science

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