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These formulations allow for direct application to the skin, where GHK-Cu can work its magic on a cellular level

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Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin

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Best Applications for (GHK)-CU This variant is primarily relevant for those formulating their own products or evaluating commercial products that list the specific ratio