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consequently, reduced or temporally/spatially mismatched Treg-derived cytokines (TGF-, IL-10, and IL-35) can weaken mucosal tolerance and reparative programs, whereas context-dependent Treg overexpansion may impair antimicrobial immunity, resulting in dysregulated intestinal homeostasis 50,51

Cinnamaldehyde-curcumin-BBR formulations (F2) enhance Akt2 phosphorylation (T450, Y475, and S474), improving insulin sensitivity without adipogenic effects in diet-induced obese mice [192, 193]

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