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Folate plays a role in transferring one-carbon units to various intermediates in DNA synthesis and methylation reactions, including the conversion of homocysteine to methionine ( Literature indicates that nearly one-third of psychiatric and psychogeriatric hospital admissions exhibit low red cell folate levels or decreased serum folate levels, even in the absence of anemia or macrocytosis (46)

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We have previously shown that this method has increased sensitivity and allows for measurement of more subtle, but significant reductions of sucrose preference when applied to the chronic mild stress model for depression