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Sayoc-Becerra A, Krishnan M, Fan S et al (2020) The JAK-inhibitor tofacitinib rescues human intestinal epithelial cells and colonoids from cytokine-induced barrier dysfunction

Anti-inflammatory signaling lowers damaging cytokines that contribute to follicle miniaturization and scalp irritation

Escalating faster than the documented ~4-week rhythm buys GI misery, not faster results

But heres the regulatory reality: FDA / Federal classification (US) Neither BPC-157 nor TB-500 is FDA-approved for any medical use in humans

Topically yes

Methods Ethics declarations All the animal experiments were performed following the Guide for Care and Use of Laboratory Animals, approved by the Animal Experimentation Ethics Committee of China Pharmaceutical University (2022-10-017)