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PLos One (2013) 8(8):e70767

A few adverse events, such as weight gain or seizures, were reported, but the connection to SFN remains uncertain, especially considering the increased seizure risk inherent to some individuals with ASD

Nutrition 26(5):563570 Gonzlez-Montelongo R, Lobo MG, Gonzlez M (2010) Antioxidant activity in banana peel extracts: Testing extraction conditions and related bioactive compounds

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This is a known consideration in freeze-dried and frozen formulation research, where excipients such as mannitol are studied specifically to protect molecules through these phase changes, as covered in the Journal of Pharmaceutical Sciences review cited above