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Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs

J Transl Med (2011) 9:81

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Characteristics, Motivations, and Preferences of Healthy Volunteers in Phase I Clinical Trials in Sweden