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2i and Extended Data Fig

A prolonged pathological inflammatory response can lead to the induction of disturbances in the redox profile of cells and, consequently, to the induction of a state of oxidative stress

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NADH-reductive stress is an emerging hallmark of diverse human pathologies, including primary mitochondrial diseases, cancer, cardiac ischemia/reperfusion injury, insulin resistance, fatty liver and dyslipidemia 411

PMID 16746382