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The mature adipocytes secrete BMP4 that triggers preadipocyte differentiation by inducing the separation of Wnt1 inducible-signaling pathway protein 2 (WISP2) and zinc finger protein 423 (ZNF423), allowing ZNF423 to translocate into the nucleus and activate peroxisome proliferator-activated receptors (PPAR) and downstream cascade including CCAAT/enhancer-binding proteins (C/EBP), , and [41, 42] ( Figure 1 )

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(Agnoli et al., 2017

Vitamin B12 is an important vitamin needed for a healthy nervous system, the formation of red blood cells, and for building DNA

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Gastrointestinal Protection : Original research showed protective effects against ulcers and inflammatory bowel conditions