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systemically examined the expression of GPxs in breast cancer cell lines and found that GPx5 and GPx7 were down-regulated in the human breast cancer MCF-7 and MDA-MB-231 cell lines and GPx6 was also down-regulated in MDA-MB-231cells compared with healthy breast MCF-10A cells [19]

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Besides H 2 O 2 , Prx2 can also remove peroxynitrites [5] and hydroperoxides in the RBC membrane [73, 75]

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