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At therapeutic IV concentrations, it modulates NMDA receptors in the brain, which reduces the calcium influx that drives migraine aura and cortical spreading depression

10.1371/journal.pone.0084996 83 KondoC.SuzukiH.ItodaM.OzawaS.SawadaJ-i.KobayashiD.et al (2004)

First Things First: Gathering Your Supplies Before you even think about opening a vial, you need to establish a clean, organized workspace and assemble the right tools

Curr Oncol Rep 2004

Quick Reference: Common Concentrations IU = insulin units on a U-100 syringe (100 IU = 1mL)

Authors are also thankful to the animal ethics committee for approving the project and providing necessary animals to conduct the study