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Inadequate vitamin B6 increases urine oxalate and kidney stone risk in laboratory animals and humans, and hyperoxaluria has been successfully reduced with vitamin B6 supplementation (Murthy 1982

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suggested that the gamma-aminobutyric acid signaling system in the liver may inhibit the immunoglobulin-regulated enhancer 1/apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase (IRE1/ASK1/JNK) cell apoptosis pathway triggered by ERS (Wang et al., 2018)

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