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The elevated growth hormone then boosts IGF-1 production in the liver and other tissues, which mediates many of GHs anabolic effects including increased protein synthesis and muscle growth, enhanced lipolysis and fat body function, improved bone density and tissue repair, enhanced collagen synthesis, and better sleep quality and healing
SURMOUNT-1 (N=2,539) showed mean weight reductions of 15.0%, 19.5%, and 20.9% at the 5 mg, 10 mg, and 15 mg doses respectively at 72 weeks, compared to 3.1% with placebo
GLP-1 side effects are usually mild and dose-dependent: nausea, constipation, and reduced appetite (which is therapeutic)
(2023) 15:e35625
D.GromesR.WangS.WirtzM.HellR.et al (2019)