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While existing animal models, which replicate specific phenotypes by targeting individual organ systems, offer the closest approximation to the HFpEF pathology, they still fall short of fully recapitulating the human condition

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PubMed Randomized trialTirzepatide evidence2022 Tirzepatide Once Weekly for the Treatment of Obesity Primary SURMOUNT-1 trial source for tirzepatide weight-loss ranges and tolerability

Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight

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