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This resealing of the gut barrier is a critical step in halting the continuous leakage of endotoxins into the bloodstream, thereby cutting off the primary fuel source for systemic neuroinflammation

thus, it was observed that chemotherapeutic agent-induced increase of TRPA1 expression, cell death and neuropathic pain in mice DRG was reduced by aluminum and GSH treatment (Lee et al., 2017)

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