(Note that the WHO defines adults as those 18 and older, so its figures arent directly comparable with the CDC data.) Worldwide, obesity affected about 663 million adults, or 13% of the global adult population, in 2016
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It is synthesized in the liver and is present in every cell of the body, where it serves as a critical antioxidant
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Additionally, IGF-1 interacts with factors like platelet-derived growth factor (PDGF) to promote the survival and proliferation of PASMCs, reducing the abnormal pulmonary vascular remodeling caused by cell death and survival imbalance, thereby delaying PAH progression ( Thus, IGF-1 exerts a dual role in PAH
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