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These include capsaicin (reduces the level of a pain transmitter called Substance P), SAMe or S-adenosylmethionine (an endogenous compound that stimulates cartilage production), and anthocyanidins (an antioxidant that prevent the degradation of collagen)
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83 Divalent ion deficiency Divalent ions such as Mg 2+ , Co 2+ , and Mn 2+ are activators of ALP, and Zn 2+ is a constituent metal ion of the enzyme
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Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ et al