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TNF, tissue necrosis factor

Liraglutide and dulaglutide, as GLP-1R agonists, can improve AD-related cognitive dysfunction by inhibiting tau protein hyperphosphorylation and NFTs formation through activation of the protein kinase B/glycogen synthase kinase 3 beta (Akt/GSK-3) signaling pathway (Shu et al., 2019

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The storage and handling of compounded formulations can also affect potency and consistency, which may influence how the medication affects various body systems

Separate phase III CVOTs of GLP1R agonists are currently being conducted in people living with heart failure with preserved ejection fraction and in those with obesity