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Nardin, A., Lefebvre, M

Nature 410 , 822825 (2001)

In this review, detailed information on drug-induced kidney injury mechanisms and available in vitro models to predict this with relevant translational biomarkers will be discussed, with an emphasis on novel developments in the field of microphysiological systems that meet the requirements of the 3Rs (replacement, reduction, refinement) of animal experiments for drug safety screenings

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Continued investigation is required to assess the formulation-dependent differences in bioavailability to ensure consistent therapeutic outcomes, optimal absorption and effective systemic distribution