Clinical course The clinical course of APAP hepatotoxicity in patients with a single overdose can be classically divided into 4 sequential stages (table below ), however, it should be noted that the course is variable and may not follow the four-stage sequential pattern seen after a single oral ingestion
Tracking neurotransmitter-related markers and hormones, such as GHRH, somatostatin surrogates, cortisol, and prolactin, helps track hypothalamic response
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Blood 103(12):4396-4407, 2004
However, centralized laboratory testing, venous blood collection, and intermittent monitoring are frequently used in conventional diagnostic techniques, which may lead to poor patient compliance and delayed diagnosis [11,12,13]
