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The activity of several hepatic nuclear receptors is reduced in patients with Wilson disease and in Atp7b-/- animal models, though it remains unclear how this contributes to the diseases pathogenesis [130]

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Extending from the GRN gene, we can study more broadly lipid accumulation related to aging and neurodegeneration 105 , which have been widely observed but lack the underlying mechanism to explain the phenotype

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The closest human evidence in Dihexa's drug class is a different molecule