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AEDG) used in controlled in-vitro research to explore telomere biology pathways, cellular senescence markers, and circadian-related peptide signalling under non-clinical conditions
The overarching material developed and investigated comprises AngIV-based compounds, designed to overcome the limitations of native peptides like AngIV, which suffer from poor metabolic stability and inability to cross the BBB due to their size and hydrophilicity
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The peptides under investigation, include: Nle-AngIV (Nle-Tyr-Ile-His-Pro-Phe) and its analogs such as D-Nle-YIH, acetyl-NleYIH, -amino butyric acid-YIH, NleYI-amide, and the primary focus, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide (Dihexa)
ACS medicinal Chem
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