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There is no published RCT and no long-term human safety data

Handa RK, Ferrario CM, Strandhoy JW

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Recent Independent Replication Al-Dulaimi et al., Biogerontology (2025) Al-Dulaimi, Thomas, Matta, and Roberts conducted an independent in vitro evaluation of Epithalons effects on telomere length in human cell lines

Research shows that methylated B12 may reduce inflammation by mitigating homocysteine (3)

Many companies may ship from Canada while still sourcing finished vials from overseas