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3.2 The Up-Stream Regulatory Mechanisms of Ferroptosis 3.2.1 System X c The cystine-glutamate antiporter System X c is a disulfide-linked heterodimer composed of a light chain XCT and a heavy chain 4F2, namely, substrate-specific subunit SLC7A11 and regulatory subunit SLC3A2 (Song et al., 2018

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The MHb-IPN circuit has downstream targets that promote nicotine aversion, prompted by GLP-1 release from NTS terminals that stimulate habenular terminals, although such targets are currently unknown [22]