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So even within KLOW, the evidence is uneven: strongest for the anchor, progressively more speculative for the supporting peptides

A physiological DPP-4 substrate is defined as one whose relative levels of intact versus cleaved peptide are significantly different in an animal or human treated with a DPP-4 inhibitor, or in an animal with genetic inactivation of DPP-4 (e.g., GIP, GLP-1, GLP-2, Peptide tyrosine tyrosine [PYY], Stromal cell-derived factor-1 [SDF], and Substance P [SP])

El-Nashar et al., 2023)

A full list of risks and contraindications will be discussed during your physician consultation

Individual patient factors, including treatment goals and comorbidities, should guide these decisions in consultation with healthcare professionals

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