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The core regulation of hypoxia adaptation is the HIF pathway, making it both a challenge and a potential therapeutic target for hypoxia- and oxidative stress-related diseases (Fig

doi: 10.3389/fendo.2020.00565 38 DaraeiMHasibiMAbdollahiHMirabdolhagh HazavehMZebaradstJHajinooriMet al