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Paccou J, Compston JE

Elevated cAMP activates protein kinase A (PKA), which phosphorylates multiple targets including ion channels, transcription factors (notably CREB), and components of the insulin secretory machinery

Common: Nausea, vomiting, diarrhea, or constipation Reduced appetite (sometimes too much) Mild low blood sugar (especially with other diabetes medications) Injection site reactions Less common but serious: Pancreatitis Gallbladder issues Kidney complications from dehydration Thyroid tumors (observed in rodent studies and still under investigation in humans) This is a non-exhaustive list

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The relationship between semaglutide and energy levels often improves once nutrition is optimized

Q: Why am I losing weight so fast, but still feel bloated or sluggish