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MITOCHONDRIAL BIOGENESIS AND OXIDATIVE CAPACITY MARKERS Cellular markers of mitochondrial biogenesis (PGC-1 expression, mitochondrial DNA content, citrate synthase activity) increase with 5-Amino-1MQ administration, confirming enhanced mitochondrial capacity at the cellular level

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In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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