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They start at a very conservative dose and over a period of months ramp to what's called a therapeutic dose, or the specific amount of medication that best addresses the target issue while minimizing side effects

Building on the therapeutic success of GLP-1RAs, recent pharmacological developments have introduced GLP-1 with glucose-dependent insulinotropic polypeptide (GIP)/glucagon (GCG) dual or triple receptor agonists simultaneously target multiple incretin pathways, offering a novel multi-targeted approach to MASLD treatment

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Comparison of mechanism, pulsatility, and research applications