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In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation

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Knockout of STK40 could cause the accumulation of c-Jun protein and subsequently impairs mesoderm differentiation 32

Neither compound, nor any other peptide on this list, substitutes for consistent resistance training, adequate protein intake, and sufficient recovery, which remain the primary drivers of muscle growth regardless of which peptide a person considers

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These unfortunate effects are strongest in the days immediately after injecting the once-weekly medication