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Although we did not find reports of a direct association between betaine and SLE, a study based on ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry suggested that the betaine pathway differed significantly between rheumatoid arthritis patients and healthy controls (Zhu et al., 2022)

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In their most recent updated recommendations on the prevention of cardiovascular disease in adults with type 2 diabetes, the American Diabetes Association and American Heart Association found insufficient evidence from large-scale randomized trials in individuals with type 2 diabetes to support the use of omega-3 fatty acid supplements (combined with a heart-healthy diet) in the prevention of cardiovascular events (118)

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(2022) Ergothioneine improves aerobic performance without any negative effect on early muscle recovery signaling in response to acute exercise

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