But what exactly are GLP-1s
T., Kadowaki T., Lingvay I., Nauck M., et al
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careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects
Studies demonstrate that GLP-1RAs, especially liraglutide and exenatide, consistently promote weight reduction and improve lipid profiles, which are critical for managing obesity and MetS, common in PCOS patients
GLP-1 is mainly found in the circulation, where it is rapidly degraded after secretion ( versus peripheral GLP-1 for alcohol drinking is uncertain
