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A long-acting peptide has to survive clearance, avoid losing activity, and keep receptor engagement in a range that doesnt either vanish (no efficacy) or spike (poor tolerability)

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Since the accumulation of uremic toxins in CKD patients engenders various neurological complications, treatments that target the significant reduction of these metabolites not only significantly delay CKD progression but also greatly improve cognitive function in these patients (Faucher et al., 2023)