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The most commonly reported adverse effects in these trials were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the broader class of GLP-1 receptor agonists

Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women123 The American Journal of Clinical Nutrition

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Participants in trials experienced significant reductions in apnea-hypopnea index (AHI), better oxygen saturation levels during sleep, and enhanced daytime alertness